Soluble CD40L, platelet surface CD40L and total platelet CD40L in congestive heart failure: relationship to platelet volume, mass and granularity
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چکیده
منابع مشابه
CD40-CD40L and platelet function: beyond hemostasis.
Traditionally, platelets have been thought of as anuclear, subcellular fragments derived from megakaryocytes circulating in blood as small discs and mitigating hemorrhage. This hemostatic process requires platelet activation, a complex chain of events involving rapid structural changes that activate adhesion receptors, remodel the cytoskeleton, and lead to the eventual synthesis and secretion o...
متن کاملThe role of platelet CD40L in inflammation
CD40L is a membrane protein belonging to the tumour necrosis factor family, originally found on activated T cells. The CD40L-CD40 interaction is of critical importance in the adaptive immune response, in innate immunity and in inflammation. Recently, activated platelets have been found to express CD40L. Platelets can stimulate endothelial cells via a CD40L-CD40 interaction to upregulate adhesio...
متن کاملPlatelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.
CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis. Although CD40L-deficient (Cd40l(-/-)) platelets exhibited impaired platelet aggregation and thrombus stability, the effects of platelet CD40L on inflammatory processes ...
متن کاملPlatelet-derived CD40L: the switch-hitting player of cardiovascular disease.
Three closely linked lines of research have now merged. In the 1980s, concepts crystallized on the role of lipids (eg, oxidized LDL, elevated cholesterol) in the genesis of atherosclerotic plaque. In the 1990s, use of antiplatelet agents proved that platelet aggregation caused thrombotic ischemic events resulting from the rupture of plaques in advanced lesions and from the vascular injuries inf...
متن کاملSoluble CD40L and cardiovascular risk in women.
BACKGROUND The immune-signaling dyad CD40/CD40L promotes atherogenesis, and patients with unstable angina have elevated plasma levels of soluble CD40L (sCD40L) and membrane-bound CD40L. It is unknown, however, whether elevations of circulating sCD40L precede the onset of acute cardiovascular symptoms. METHODS AND RESULTS In a prospective, nested case-control evaluation of healthy middle-aged ...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2008
ISSN: 0954-6820,1365-2796
DOI: 10.1111/j.1365-2796.2007.01891.x